Cook noodles according to package directions. Drain water.
In a large bowl, combine the cooked pasta, chicken, frozen veggies, milk, cream of mushroom, cream of chicken, salt, pepper, onion powder, melted butter, garlic powder, and Italian seasoning.
Spray a casserole dish (9 x 13) with cooking spray or grease it.
Pour pasta mixture into dish and spread evenly.
Sprinkle cheese and crushed cracker on top of casserole.
Bake in a preheated oven, 350, for 30 minutes covered with foil, 10 minutes uncovered.